Reaktion #445622

ord-4a642743f69e4636afe81961a31aaef1

Reaktionsgleichung

CC(=O)Oc1cc2[nH]cc(C(=O)O)c(=O)c2cc1OC(C)=O
6,7-Diacetoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
O=S(Cl)Cl
thionyl chloride
→
CC(=O)Oc1cc2[nH]cc(C(=O)Cl)c(=O)c2cc1OC(C)=O
6,7-diacetoxy-1,4-dihydro-4-oxoquinoline-3-carbonyl chloride

Edukte

CC(=O)Oc1cc2[nH]cc(C(=O)O)c(=O)c2cc1OC(C)=O
6,7-Diacetoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
O=S(Cl)Cl
thionyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe solvent was evaporated
  2. 2
    workup.ADDITIONTo the residue was added benzene (30 mL)
  3. 3
    SonstigeBenzene was evaporated
  4. 4
    Sonstigedried

Vorschrift

6,7-Diacetoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (70 mg) was heated under reflux for 2 hours in thionyl chloride (2 mL), and then the solvent was evaporated. To the residue was added benzene (30 mL). Benzene was evaporated and the residue was vacuum dried to give 6,7-diacetoxy-1,4-dihydro-4-oxoquinoline-3-carbonyl chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04468394uspto-grants-1984_08