Reaktion #4455

Reaktionsgleichung

N-amino-1,2,3,6-tetrahydropyridine hydrochloride

triethylami-ne

phenyl chloroformate

→

N-(phenoxy- carbonylamino)-1,2,3,6-tetrahydropyridine

Ausbeute 92.1%

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeEvaporation of the solvent
2. 2
   Sonstigegave a residue, which
3. 3
   Extraktionwas extracted with ethyl acetate (150 ml)
4. 4
   WaschenThe extract was washed with water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   SonstigeThe solvent was evaporated in vacuo

Vorschrift

To a solution of N-amino-1,2,3,6-tetrahydropyridine hydrochloride (1.346 g) and triethylami-ne (2.024 g) in methylene chloride (60 ml) was added a solution of phenyl chloroformate (1.566 g) in methylene chloride (40 ml) and the mixture was stirred for 4 hours at 5° C. Evaporation of the solvent gave a residue, which was extracted with ethyl acetate (150 ml). The extract was washed with water and dried over magnesium sulfate. The solvent was evaporated in vacuo to give N-(phenoxy- carbonylamino)-1,2,3,6-tetrahydropyridine (2.01 g), which was recrystallized from diisopropyl ether to give the desired compound (0.732 g) as colorless needles. mp: 124°-125.5° C.

Quelle