Reaktion #44506

Reaktionsgleichung

solution

4-(tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester

HCl

→

titled compound

4-hydroxy-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo
2. 2
   Sonstigethe residue was purified by flash column chromatography (hexanes; ethyl acetate 100:0 to 50:50)

Vorschrift

A solution of Example 8D (2.2 g, 5.0 mmoles) was taken in ethanol (8 mL) and 12M HCl (1 mL) was added. The reaction was stirred at room temperature for twelve hours. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (hexanes; ethyl acetate 100:0 to 50:50) to obtain the titled compound as a mixture of diastereomers.

Quelle