Reaktion #44505

Reaktionsgleichung

solution

tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane

ethyl diazoacetate

→

title compound

4-(tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo and product
2. 2
   Sonstigepurified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20)

Vorschrift

To a solution of Example 8C (2.2 g, 6.28 mmoles) and Rh2(OAc)4 (2 mg, 4.3 μmol) in dichloromethane (2 mL), ethyl diazoacetate (0.717 g, 6.28 mmoles) in dichloromethane (4 mL) was added over two hours via a syringe pump. The solvent was evaporated in vacuo and product purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20) to provide the title compound.

Quelle