Reaktion #444849

Reaktionsgleichung

AlCl3

isobutylbenzene

2-bromoisobutyryl bromide

→

2-Methyl-5-isobutyl-1-indanone

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling with ice
2. 2
   TemperaturThe mixture was heated
3. 3
   Temperaturunder reflux for a further 15 hours
4. 4
   SonstigeThe crude product was chromatographed on 100 g of silica gel (hexane/methylene chloride 1:1)

Vorschrift

17.3 g (125 mmol) of AlCl3 were added to a solution of 6.71 g (50 mmol) of isobutylbenzene in 30 ml of analytical grade methylene chloride, while cooling with ice. 11.9 g (52 mmol) of 2-bromoisobutyryl bromide were then added rapidly, and stirring was continued at 0° C. for 1 hour and at room temperature for 2 hours. The mixture was heated under reflux for a further 15 hours and then worked up analogously to Example A. The crude product was chromatographed on 100 g of silica gel (hexane/methylene chloride 1:1). The yield was 8.42 g (83%).

Quelle