Reaktion #44484

ord-272aeb37cfe24c39bb51f81365c79ccf

Reaktionsgleichung

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one
→
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
title compound
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

Edukte

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Reagenzien

Cl
HCl

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvent was evaporated in vacuo

Vorschrift

Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737137B2uspto-grants-2010_06