Reaktion #44480

Reaktionsgleichung

N-(tert-butoxycarbonyl)-hexahydro-1H-azepin-4-one

O-benzylhydroxylamine hydrochloride

ammonium acetate

→

title compound

4-Amino-azepane-1-carboxylic acid tert-butyl ester

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo
2. 2
   Sonstigethe crude oxime was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 50:50)
3. 3
   workup.ADDITIONadded 10% by weight Pd/C (100 mg)
4. 4
   FiltrationThe reaction was filtered through a pad of celite and filtrate
5. 5
   Sonstigeevaporated in vacuo

Vorschrift

A solution of N-(tert-butoxycarbonyl)-hexahydro-1H-azepin-4-one (0.5 g, 2.34 mmoles), O-benzylhydroxylamine hydrochloride (0.41 g, 2.57 mmoles) and ammonium acetate (0.45 g, 5.86 mmoles) in methanol (10 mL) was refluxed for 1.2 hours. The solvent was evaporated in vacuo and the crude oxime was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 50:50). The product was taken in 4N NH3 in methanol (10 mL) and added 10% by weight Pd/C (100 mg) and stirred over H2 at balloon pressure for twelve hours. The reaction was filtered through a pad of celite and filtrate evaporated in vacuo to provide the title compound.

Quelle