Reaktion #44477

Reaktionsgleichung

dimethyl itaconate

cycloheptylamine

→

title compound

1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo
2. 2
   Sonstigethe resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80)

Vorschrift

A solution of dimethyl itaconate (0.5 g, 3.16 mmoles), cycloheptylamine (0.357 g, 3.16 mmoles) in methanol (5 mL) was heated at 85° C. for eighteen hours. The solvent was evaporated in vacuo and the resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80) to give the title compound as a colorless oil.

Quelle