Reaktion #44453

Reaktionsgleichung

Cs2CO3

phenol

Water

1,4-dibromo-2-nitrobenzene

→

crude compound

Ausbeute 108.8%

4-Bromo-2-nitro-1-phenoxybenzene

Ausbeute 108.8%

Lösungsmittel

THF

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe resulting mixture was heated
2. 2
   Temperaturto reflux
3. 3
   workup.STIRRINGstirred overnight
4. 4
   Temperaturat reflux
5. 5
   Extraktionfollowed by extraction with ethyl acetate (3×)
6. 6
   WaschenThe combined organic layers were washed with water and brine
7. 7
   Trocknendried (Na2SO4)
8. 8
   Sonstigeevaporated

Vorschrift

Cs2CO3 (4 g, 12.3 mmol) was added to a solution of phenol (1 g, 10.6 mmol) in 50 mL of THF under N2 atmosphere. After stirring for 15 min. 1,4-dibromo-2-nitrobenzene (2.81 g, 10 mmol) was added. The resulting mixture was heated to reflux and stirred overnight at reflux. Water and ethyl acetate were added, followed by extraction with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried (Na2SO4) and evaporated to give the crude compound (3.2 g, 75%).

Quelle