Reaktion #44420

Reaktionsgleichung

water

(1S)-1-(3,4-Difluorophenyl)ethanamine

2,6-dichloropyrazine

potassium carbonate

→

pyrazine

Ausbeute 35.1%

6-Chloro-N-[(1S)-1-(3,4-difluorophenyl)ethyl]pyrazin-2-amine

Ausbeute 35.1%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was then heated
2. 2
   SonstigeThe crude reaction mixture
3. 3
   Extraktionextracted with diethyl ether (3×30 mL)
4. 4
   EinengenThe combined organic extracts were concentrated
5. 5
   Sonstige20 g silica cartridge (8:2 petroleum spirits:ethyl acetate, followed by ethyl acetate flush)

Vorschrift

(1S)-1-(3,4-Difluorophenyl)ethanamine (977 mg, 6.2 mmol) and 2,6-dichloropyrazine (1.236 g, 8.3 mmol, 1.3 eq) was dissolved in dioxane (5 mL) and potassium carbonate (1.73 g, 2.0 eq) added to the solution. The mixture was then heated at reflux (110° C.) under a nitrogen atmosphere for 65 hours. The crude reaction mixture was then poured onto cold water (30 mL) and extracted with diethyl ether (3×30 mL). The combined organic extracts were concentrated and subjected to flashmaster chromatography (20 g silica cartridge (8:2 petroleum spirits:ethyl acetate, followed by ethyl acetate flush) to afford the desired pyrazine-adduct as an off-white solid (587 mg, 35%).

Quelle