Reaktion #444141

Reaktionsgleichung

sodium nitrite

sodium tetrafluoroborate

hydrochloric acid

3-cyclopentyloxy-4-methoxyaniline

→

3-cyclopentyloxy-4-methoxyphenyldiazonium tetrafluoroborate

Ausbeute 101.2%

Lösungsmittel

water

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeremains from 0° C. and 5° C
2. 2
   Sonstigethe temperature below 5° C
3. 3
   TemperaturThe stirred solution, while still maintained at below 5° C.
4. 4
   FiltrationThe resulting precipitate is filtered off
5. 5
   Waschenwashed with cold water (3 mL)
6. 6
   Sonstigedried in vacuo

Vorschrift

A stirred solution of concentrated hydrochloric acid (1.7 mL) in water (5 mL) from 0° C. and 5° C. is treated with 3-cyclopentyloxy-4-methoxyaniline (0.83 g), followed by a solution of sodium nitrite (0.29 g) in water (0.6 mL), at such a rate that the temperature remains from 0° C. and 5° C. The resulting solution is stirred for a further 10 minutes, while keeping the temperature below 5° C. The stirred solution, while still maintained at below 5° C., is then treated dropwise with a solution of sodium tetrafluoroborate (0.88 g) in water (1.8 mL). The resulting precipitate is filtered off, washed with cold water (3 mL) and dried in vacuo, to give 3-cyclopentyloxy-4-methoxyphenyldiazonium tetrafluoroborate (1.24 g) in the form of a gray solid, m.p. 120° C.

Quelle