Reaktion #44390

ord-dff6b5a0db1547c19bd0363b932ca948

Reaktionsgleichung

C[C@H](Oc1ccc(C(F)(F)F)cc1-c1ccc(C(=O)NC(C)(C)C)c(F)c1)C(=O)O

C[C@H](Oc1ccc(C(F)(F)F)cc1-c1ccc(C(=O)NC(C)(C)C)c(F)c1)C(=O)O

(2S)-2-[[4′-[[(1,1-dimethylethyl)amino]carbonyl]-3′-fluoro-5-(trifluoromethyl)[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

→

C[C@H](Oc1ccc(Cl)cc1-c1ccc(C(=O)NC(C)(C)C)c(F)c1)C(=O)O

C[C@H](Oc1ccc(Cl)cc1-c1ccc(C(=O)NC(C)(C)C)c(F)c1)C(=O)O

(2S)-2-[[5-chloro-4′-[[(1,1-dimethylethyl)amino]carbonyl]-3′-fluoro[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

Edukte

(2S)-2-[[4′-[[(1,1-dimethylethyl)amino]carbonyl]-3′-fluoro-5-(trifluoromethyl)[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737135B2uspto-grants-2010_06