Reaktion #44388

ord-4e93548824f9466bac4bbaa5e68fff4a

Reaktionsgleichung

CC(C)NC(=O)c1ccc(-c2cc(Cl)ccc2O[C@@H](C)C(=O)O)cc1F
product
CC(C)NC(=O)c1ccc(-c2cc(Cl)ccc2O[C@@H](C)C(=O)O)cc1F
(2S)-2-[[5-chloro-3′-fluoro-4′-[[(1-methylethyl)amino]carbonyl][1,1′-biphenyl]-2-yl]oxy]-propanoic acid
C[C@H](Oc1ccc(C(F)(F)F)cc1B(O)O)C(=O)O
(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid
→
CC(C)NC(=O)c1ccc(-c2cc(C(F)(F)F)ccc2O[C@@H](C)C(=O)O)cc1F
title compound
CC(C)NC(=O)c1ccc(-c2cc(C(F)(F)F)ccc2O[C@@H](C)C(=O)O)cc1F
(2S)-2-[[3′-fluoro-4′-[[(1-methylethyl)amino]carbonyl]-5-(trifluoromethyl)[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

Edukte

CC(C)NC(=O)c1ccc(-c2cc(Cl)ccc2O[C@@H](C)C(=O)O)cc1F
product
CC(C)NC(=O)c1ccc(-c2cc(Cl)ccc2O[C@@H](C)C(=O)O)cc1F
(2S)-2-[[5-chloro-3′-fluoro-4′-[[(1-methylethyl)amino]carbonyl][1,1′-biphenyl]-2-yl]oxy]-propanoic acid
C[C@H](Oc1ccc(C(F)(F)F)cc1B(O)O)C(=O)O
(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared using the product of example 34 step a) and (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid [WO2004089885] by the method of example 32 step b).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737135B2uspto-grants-2010_06