Reaktion #443877

Reaktionsgleichung

docosanol

oxalyl chloride

oxalyl chloride

→

docosyl chlorooxalate

Ausbeute 92.5%

Reaktionsbedingungen

Vorschrift

In this example the product was prepared in two synthetic steps. In the first step docosanol was reacted with 50% molar excess of oxalyl chloride. Upon completion of the reaction the excess oxalyl chloride was stripped from the product at reduced pressure to produce docosyl chlorooxalate having an assay of 91.4% and in a corrected yield of 92.5%. In the second step docosyl chlorooxalate was reacted with 2,5-dimethyl-2,5-dihydroperoxyhexane, in the presence of pyridine, to yield the product:

Quelle