Reaktion #443863

Reaktionsgleichung

trans-1-tert-butoxycarbonyl-3-fluoro-4-[2-(trifluoromethyl)benzylamino]piperidine

trifluoroacetic acid

→

title compound

Ausbeute 97.0%

trans-3-Fluoro-4-[2-(trifluoromethyl)benzylamino]piperidine

Ausbeute 97.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Vorschrift

Using a similar procedure to that described in Example 1, step 4, trans-1-tert-butoxycarbonyl-3-fluoro-4-[2-(trifluoromethyl)benzylamino]piperidine (0.4615 g, 1.23 mmol) was reacted with trifluoroacetic acid (1.5 mL) in dichloromethane (3 mL) to give 0.3292 g (97%) of the title compound as a colourless oil. δH (360 MHz, CDCl3) 1.35 (1H, m), 2.02 (1H, m), 2.55-2.69 (2H, m), 2.82 (1H, m), 2.99 (1H, m), 3.31 (1H, m), 4.02 (2H, m), 4.34 (1H, two m), 7.35 (1H, t, J=7.6 Hz), 7.53 (1H, t, J=7.6 Hz), 7.63-7.67 (2H, m). m/e (ES+) 277 (M+H)+.

Quelle