Reaktion #443862

ord-a59642f0afa14f33aa6dfffa958ddb91

Reaktionsgleichung

C[C@@H](N[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1F)c1ccccc1
trans-1-tert-butoxycarbonyl-3-fluoro-4-[(1R)-1-phenylethylamino]piperidine
O=C(O)C(F)(F)F
trifluoroacetic acid
→
C[C@@H](N[C@@H]1CCNC[C@H]1F)c1ccccc1
title compound
Ausbeute 96.0%
C[C@@H](N[C@@H]1CCNC[C@H]1F)c1ccccc1
trans-3-Fluoro-4-[(1R)-1-phenylethylamino]piperidine
Ausbeute 96.0%

Edukte

C[C@@H](N[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1F)c1ccccc1
trans-1-tert-butoxycarbonyl-3-fluoro-4-[(1R)-1-phenylethylamino]piperidine
O=C(O)C(F)(F)F
trifluoroacetic acid

Reagenzien

Keine

Lösungsmittel

ClCCl
dichloromethane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using a similar procedure to that described in Example 1, step 4, trans-1-tert-butoxycarbonyl-3-fluoro-4-[(1R)-1-phenylethylamino]piperidine (0.1147 g, 0.356 mmol) was reacted with trifluoroacetic acid (0.5 mL) in dichloromethane (1.0 mL) to give 75.6 mg (96%) of the title compound as a colourless oil. δH (250 MHz, CDCl3) 1.19 (1H, m), 1.35 (3H, d, J=6.6 Hz), 1.68 (1H, m), 2.40-2.73 (3H, m), 2.85 (1H, m), 3.26 (1H, m), 3.99 (1H, q, J=6.6 Hz), 4.28 (1H, two m, J=49.8 Hz), 7.20-7.35 (5H, m).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05837715uspto-grants-1998_11