Reaktion #44378

Reaktionsgleichung

product

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

product

4-bromo-2-fluoro-N,N-bis(1-methylethyl)-benzamide

sodium carbonate

→

title compound

(2S)-2-[[4′-[[bis(1-methylethyl)amino]carbonyl]-5-chloro-3′-fluoro[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

Lösungsmittel

dioxan

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 24 h
3. 3
   Filtrationfiltered (hyflo)
4. 4
   EinengenThe filtrate was concentrated in vacuo
5. 5
   Sonstigepurified by reverse phase HPLC

Vorschrift

The product of step c) (200 mg), the product of step d) (200 mg), Pd(dppf)Cl2 (60 mg), sodium carbonate (350 mg) and dioxan (5 ml) were charged to a flask and heated at reflux for 24 h, then cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then purified by reverse phase HPLC to give the title compound. Yield 22 mg

Quelle