Reaktion #44370

ord-45dfeeb0b58d44f2a266dbeddef52e11

Reaktionsgleichung

C[C@@H]1CCC[C@H](C)N1C(=O)c1ccc(-c2cc(Cl)ccc2OCC(=O)O)cc1Cl
product
C[C@@H]1CCC[C@H](C)N1C(=O)c1ccc(-c2cc(Cl)ccc2OCC(=O)O)cc1Cl
[[3′,5-dichloro-4′-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl][1,1′-biphenyl]-2-yl]oxy]-acetic acid
C1CNOC1
isoxazolidine
→
COc1ccc(Cl)cc1-c1ccc(C(=O)N2CCCO2)c(Cl)c1
sub-title compound
COc1ccc(Cl)cc1-c1ccc(C(=O)N2CCCO2)c(Cl)c1
2-[(3,5′-dichloro-2′-methoxy[1,1′-biphenyl]-4-yl)carbonyl]-isoxazolidine

Edukte

C[C@@H]1CCC[C@H](C)N1C(=O)c1ccc(-c2cc(Cl)ccc2OCC(=O)O)cc1Cl
product
C[C@@H]1CCC[C@H](C)N1C(=O)c1ccc(-c2cc(Cl)ccc2OCC(=O)O)cc1Cl
[[3′,5-dichloro-4′-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl][1,1′-biphenyl]-2-yl]oxy]-acetic acid
C1CNOC1
isoxazolidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The sub-title compound was prepared by the method of example 21 step b) using the product of example 21 step a) and isoxazolidine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737135B2uspto-grants-2010_06