Reaktion #44363

Reaktionsgleichung

Boron tribromide

product

[5′-Chloro-2′-(phenylmethoxy)-3-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl-morpholine

→

sub-title compound

4-[[5′-Chloro-2′-hydroxy-3-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]morpholine

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethen quenched with water
2. 2
   ExtraktionThe mixture was extracted with DCM (three times)
3. 3
   Trocknenthe organic extracts were dried (MgSO4)
4. 4
   Sonstigeevaporated
5. 5
   Sonstigepurified by chromatography (silica, petrol-ether as eluent)

Vorschrift

Boron tribromide (2.5 ml, 1.0 M in DCM) was added to a solution of the product from step b) (1.16 g) in DCM (15 ml) at 0° C. The solution was stirred for 15 min then quenched with water. The mixture was extracted with DCM (three times), the organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (851 mg).

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