Reaktion #44362

Reaktionsgleichung

Morpholine

[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride

Water

→

sub-title compound

4-[[4-Bromo-2-(trifluoromethyl)phenyl]sulfonyl]morpholine

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with DCM
2. 2
   TrocknenThe organic extracts were dried (MgSO4)
3. 3
   Sonstigeevaporated
4. 4
   Sonstigepurified by chromatography (silica, petrol-ether as eluent)

Vorschrift

Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound 2.10 g).

Quelle