Reaktion #4436

Reaktionsgleichung

6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine

triethylamine

2,4-dichloro-5-sulfamoylbenzoyl chloride

→

4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

Ausbeute 71.5%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with water
2. 2
   Trocknendried over magnesium sulfate
3. 3
   Sonstigeevaporated
4. 4
   SonstigeThe obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v)

Vorschrift

To a solution of 6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine (0.8 g) in chloroform (10 ml) were added triethylamine (0.39 ml) and 2,4-dichloro-5-sulfamoylbenzoyl chloride (0.74 g), and the mixture was stirred at ambient temperature for 20 hours. The reaction mixture was washed with water, dried over magnesium sulfate, and evaporated. The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v), to give 4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.03 g).

Quelle