Reaktion #44359

Reaktionsgleichung

HCl

5-chloro-2-iodophenol

methyl bromoacetate

potassium carbonate

→

sub-title compound

Methyl (4-chloro-2-iodophenoxy)acetate

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 2 h
3. 3
   Extraktionthe mixture was extracted with ether (three times)
4. 4
   TrocknenThe organic extracts were dried (MgSO4)
5. 5
   Sonstigeevaporated
6. 6
   Sonstigepurified by chromatography (silica, petrol ether as eluent)

Vorschrift

A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol ether as eluent) to give the sub-title compound (5.75 g).

Quelle