Reaktion #44351

Reaktionsgleichung

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

→

title compound

[[3′,5-Dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

Lösungsmittel

TFA

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe mixture was azeotroped with toluene
3. 3
   Sonstigepurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

Vorschrift

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

Quelle