Reaktion #44349

Reaktionsgleichung

HCl

Butyl lithium

product

4-Bromo-2-chloro-1-(methylthio)benzene

triisopropylborate

→

sub-title compound

[3-Chloro-4-(methylthio)phenyl]boronic acid

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ether (three times)
2. 2
   TrocknenThe organic extracts were dried (MgSO4)
3. 3
   Sonstigeevaporated
4. 4
   Sonstigepurified by chromatography (silica, petrol-ether as eluent)

Vorschrift

Butyl lithium (15 ml, 1.9M in hexanes) was added over 40 min to a solution of the product from step b) (6.82 g) and triisopropylborate (8.0 ml) in THF (30 ml) at −78° C. and stirred for a further 1 h. 2M HCl (20 ml) was added, the mixture was warmed to 20° C. and extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (1.82 g).

Quelle