Reaktion #443244

ord-ea4b84b3fdd04bd0bc8629ddaf61bb25

Reaktionsgleichung

CC(C)(C)c1cc2c(cc1Cl)NCC2
6-Chloro-5-tert-butylindoline
O=C=Nc1cccnc1
3-pyridylisocyanate
→
CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2
title compound
Ausbeute 35.0%
CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2
6-Chloro-5-tert-butyl-1-(3-pyridylcarbamoyl)indoline
Ausbeute 35.0%

Edukte

CC(C)(C)c1cc2c(cc1Cl)NCC2
6-Chloro-5-tert-butylindoline
O=C=Nc1cccnc1
3-pyridylisocyanate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was recrystallised from ethanol/diethyl ether

Vorschrift

6-Chloro-5-tert-butylindoline (D56) (0.21 g, 1.01 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol/diethyl ether to give the title compound (0.12 g, 35%) as a white crystalline solid m.p.=200° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05834494uspto-grants-1998_11