Reaktion #443227

ord-5a13965fc6b64fd0ba70358fb0b19973

Reaktionsgleichung

CCCSc1cc2c(cc1Br)N(C(C)=O)CC2
thiol
CCCSc1cc2c(cc1Br)N(C(C)=O)CC2
1-Acetyl-6-bromo-5-propylthioindoline
O=C([O-])[O-].[K+].[K+]
K2CO3
CI
iodomethane
→
CSc1cc2c(cc1Br)N(C(C)=O)CC2
title compound
Ausbeute 92.1%
CSc1cc2c(cc1Br)N(C(C)=O)CC2
1-Acetyl-6-bromo-5-methylthioindoline
Ausbeute 92.1%

Edukte

CCCSc1cc2c(cc1Br)N(C(C)=O)CC2
thiol
CCCSc1cc2c(cc1Br)N(C(C)=O)CC2
1-Acetyl-6-bromo-5-propylthioindoline
O=C([O-])[O-].[K+].[K+]
K2CO3
CI
iodomethane

Reagenzien

Keine

Lösungsmittel

CS(C)=O
DMSO

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The thiol (D79) (0.35 g, 1.29 mmol) was treated with K2CO3 (0.20 g, 1.45 mmol) and iodomethane (0.24 ml, 3.85 mmol) in DMSO (15 ml) at 50° C. as in the method of Description 80 to afford the title compound (0.34 g, 92%) as an off-white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05834494uspto-grants-1998_11