Reaktion #443112

Reaktionsgleichung

N-[4-[(6,11-dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-2-methylbenzamide

tetrahydrofuran

sodium hydride

N,N-dimethylmethylene ammonium iodide

→

desired product

N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)-carbonyl]phenyl]-N-[(dimethylamino)methyl]-2-methylbenzamide

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGby stirring for 2 hours
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe filtrate is evaporated in vacuo to a residue which
4. 4
   workup.STIRRINGis stirred with hexanes

Vorschrift

To a suspension of 14 mg of 60% sodium hydride in oil, in 2 ml of tetrahydrofuran is added 0.13 g of N-[4-[(6,11-dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-2-methylbenzamide. The reactants are stirred for 1 hour and 62 mg of N,N-dimethylmethylene ammonium iodide added followed by stirring for 2 hours. The mixture is diluted with 10 ml of ether and filtered. The filtrate is evaporated in vacuo to a residue which is stirred with hexanes to give 0.13 g of the desired product as a white solid, m.p. 131°-133° C.

Quelle