Reaktion #44308

ord-0d1d811887594b48876707271c6f6132

Reaktionsgleichung

C[C@@H]1OC(=O)[C@H](C)OC1=O
L-lactide
O=C1COC(=O)CO1
glycollide
→
CC(O)C(=O)O.O=C(O)CO.O=C1CCCCCO1
lactic acid glycolic acid ε-caprolactone

Edukte

C[C@@H]1OC(=O)[C@H](C)OC1=O
L-lactide
O=C1COC(=O)CO1
glycollide

Reagenzien

O=C1CCCCCO1
ε-caprolactone
CCCCCCCC(=O)[O-].CCCCCCCC(=O)[O-].CCCCCCCC(=O)[O-].CCCCCCCC(=O)[O-].[Sn+4]
tin octanoate

Lösungsmittel

ClC(Cl)Cl
chloroform

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeA reactor equipped with an exhaust vent
  2. 2
    Sonstigefollowed by polymerization at 190° C. for 24 hours
  3. 3
    SonstigeAfter the reaction
  4. 4
    Sonstigepurified by precipitation in methanol

Vorschrift

A reactor equipped with an exhaust vent and a thermometer was charged with 263 g of L-lactide (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.), 42 g of glycollide (prepared under the same conditions as those in Example 1), 194 g of ε-caprolactone (reagent, supplied by TOKYO CHEMICAL INDUSTRY CO., LTD.) and 0.01 g of tin octanoate (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.) as a catalyst, and the pressure inside the reactor was reduced to 1×10−3 mmHg with a vacuum pump, followed by polymerization at 190° C. for 24 hours. After the reaction, a copolymer was dissolved in chloroform and purified by precipitation in methanol, to give a lactic acid/glycolic acid/ε-caprolactone copolymer.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07736393B2uspto-grants-2010_06