Reaktion #443077

Reaktionsgleichung

5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine

2-(trifluoromethoxy)benzoyl chloride

triethylamine

→

crystals

Ausbeute 69.7%

N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-2-(trifluoromethoxy)benzamide

Ausbeute 69.7%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product is triturated with dichloromethane-hexane

Vorschrift

As described for Example 9, 0.314 g (1.0 mmol) of 5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine is reacted with 0.247 g (1.1 mmol) of 2-(trifluoromethoxy)benzoyl chloride and 0.111 g (1.1 mmol) of triethylamine in 10 ml of dichloromethane at room temperature for 1.5 hours. The product is triturated with dichloromethane-hexane to give 0.35 g of crystals, m.p. 232°-235° C.

Quelle