Reaktion #442939

Reaktionsgleichung

2-(5-bromo-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole

PhCH2CH2MgBr

→

2-(5-bromo-2-(phenethyl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole

Ausbeute 103.1%

Lösungsmittel

THF

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvents evaporated
2. 2
   Sonstigethe residue partitioned between ethyl acetate and saturated aqueous ammonium chloride
3. 3
   SonstigeThe organic layer was separated
4. 4
   Sonstigeevaporated
5. 5
   Sonstigethe resulting residue purified by MPLC
6. 6
   Wascheneluting with dichloromethane

Vorschrift

To a solution of 2-(5-bromo-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole (31.21 g) in THF (40 ml) was added PhCH2CH2MgBr (0.22 mol) as a solution in diethyl ether (240 ml). The mixture was stirred for 18 hours, the solvents evaporated and the residue partitioned between ethyl acetate and saturated aqueous ammonium chloride. The organic layer was separated, evaporated and the resulting residue purified by MPLC eluting with dichloromethane to give 2-(5-bromo-2-(phenethyl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole (40.56 g).

Quelle