Reaktion #44199

Reaktionsgleichung

Cyanogen bromide

4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid hydrazide

cyanogen bromide

NaHCO3

→

desired product

Ausbeute 89.2%

5-(5-amino-[1,3,4]oxadiazol-2-yl)-4-(4-bromo-2-fluorophenylamino)-3-fluoro-1-methyl-1H-pyridin-2-one

Ausbeute 89.2%

Lösungsmittel

water

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter 19 hours
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe combined organic extracts were washed with brine
4. 4
   Trocknendried (MgSO4)
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeCrystallization (MeOH:THF)

Vorschrift

Cyanogen bromide (36 mg, 0.31 mmol) was added to a suspension of 4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid hydrazide (63 mg, 0.169 mmol) in dioxane (2 mL) followed by an aqueous NaHCO3 (2 mL of a 0.09 M solution) solution. After 17 hours, additional cyanogen bromide (14 mg) was added. After 19 hours, the reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated under reduced pressure. Crystallization (MeOH:THF) followed by trituration (Et2O:MeOH 5:1) gave clean desired product as a white solid (60 mg, 89%). MS APCI (+) m/z 398, 400 (M+, Br pattern) detected; 1H NMR (400 MHz, CD3OD) δ 8.06 (s, 1H), 7.37 (d, 1H), 7.31 (d, 1H), 7.10 (td, 1H), 3.64 (s, 3H).

Quelle