Reaktion #441979

Reaktionsgleichung

2-phenyl-4-chloroquinazoline

1-(2-pyridyl) piperazine

→

2-Phenyl-4-[4-(2-pyridinyl)-1-piperazinyl]quinazoline

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   Filtrationwas filtered
3. 3
   workup.DISSOLUTIONThe crystalline solid was dissolved in 400 ml of 3 N hydrochloric acid
4. 4
   Waschenthe aqueous acidic liquid was washed with ether
5. 5
   Sonstigeprecipitated crystalline solid
6. 6
   Sonstige6.8 g, m.p. 164°-166° C. (air dried)

Vorschrift

A mixture containing 9.6 g (0.04 mole) of 2-phenyl-4-chloroquinazoline, 6.4 g. (0.04 mole) of 1-(2-pyridyl) piperazine and 250 ml of isopropanol was refluxed for 4 hrs. The resulting reaction mixture was filtered after cooling to room temperature. The crystalline solid was dissolved in 400 ml of 3 N hydrochloric acid and the aqueous acidic liquid was washed with ether. The aqueous layer was adjusted to pH=7.5 which precipitated crystalline solid. This acidification and basification were repeated once. Yield of product was 6.8 g, m.p. 164°-166° C. (air dried).

Quelle