Reaktion #441978

Reaktionsgleichung

3-o-methoxyphenoxypyrrolidine

4-chloro-2-phenylquinazoline

→

4-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturthe mixture refluxed for 15 min
3. 3
   Sonstigesubsided to room temperature
4. 4
   Sonstigeafter standing at room temperature for 11
5. 5
   Sonstige2 hr
6. 6
   Sonstigethe resulting reaction mixture
7. 7
   Filtrationwas filtered
8. 8
   SonstigeThe crystalline solid was recrystallized with isopropanol

Vorschrift

To a solution containing 150 ml of isopropanol and 4.8 g (0.025 mole) of 3-o-methoxyphenoxypyrrolidine was added, with stirring, 6.15 g (0.025 mole) of 4-chloro-2-phenylquinazoline. The reaction was exothermic and the mixture refluxed for 15 min. The temperature subsided to room temperature and, after standing at room temperature for 11/2 hr, the resulting reaction mixture was filtered. The crystalline solid was recrystallized with isopropanol. Yield of product was 1.9 g, m.p. 142°-144° C.

Quelle