Reaktion #441976

Reaktionsgleichung

phenyl-4-chloroquinazoline

2-amino-2-methyl-1-propanol

→

title compound

2-Methyl-2-[(2-phenyl-4-quinazolinyl)amino]-1-propanol

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 4 hrs
2. 2
   Filtrationfiltered
3. 3
   Filtrationfiltered
4. 4
   EinengenThe filtrate was concentrated to dryness under reduced pressure
5. 5
   SonstigeThe semi-solid residue was recrystallized with water

Vorschrift

A mixture containing 12 g (0.05 mole) of 2 phenyl-4-chloroquinazoline, 4.5 g (0.05 mole) of 2-amino-2-methyl-1-propanol and 150 ml of isopropanol was refluxed for 4 hrs and filtered. The reaction mixture cooled to room temperature and filtered. The filtrate was concentrated to dryness under reduced pressure. The semi-solid residue was recrystallized with water to give 2.2 g of the title compound, m.p. 136°-138° C.

Quelle