Reaktion #441965

Reaktionsgleichung

5-(3-chloro-propionyl)-5,10-dihydro-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one

2-ethyl-piperidine

→

hydrochloride

Ausbeute 58.8%

5,10-Dihydro-5-[3-(2-ethyl-piperidino)-propionyl]-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one hydrochloride

Ausbeute 58.8%

Lösungsmittel

n-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter recrystallization from a mixture

Vorschrift

8.5 gm (0.027 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-10-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one and 8.5 gm (0.075 mol) of 2-ethyl-piperidine were refluxed in 85 ml of n-propanol for 3 hours, and the reaction mixture was worked up as described in Example 10. After recrystallization from a mixture consisting of equal parts of dioxane and acetone, 6.8 gm of the hydrochloride were obtained.

Quelle