Reaktion #441859

Reaktionsgleichung

6-(p-aminophenyl)-4,5-dihydropyridaz-3-one

2-chloropropionyl chloride

→

6-[p-(2-chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one

Ausbeute 93.0%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe product is filtered off at 10° C.
2. 2
   Waschenwashed first with benzene
3. 3
   Trocknenwith water and dried under reduced pressure at 100° C

Vorschrift

47.2 g (0.25 mole) of 6-(p-aminophenyl)-4,5-dihydropyridaz-3-one and 35.6 g (0.28 mole) of 2-chloropropionyl chloride in 250 ml of absolute benzene are refluxed for 2 hours. The product is filtered off at 10° C., washed first with benzene and then with water and dried under reduced pressure at 100° C. 64.8 g (93% of theory) of 6-[p-(2-chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one are obtained as a beige solid which, after recrystallization from propanol, melts, with decomposition, at 243°-244° C.

Quelle