Reaktion #44156

ord-bbab621c1e3b4c94b45ab537ff5a5d8b

Reaktionsgleichung

OCCc1cccc(Br)c1
2-(3-bromophenyl)ethanol
O=C1CCCN1
2-pyrrolidinone
O=C1CCCN1c1cccc(CCO)c1
title compound
Ausbeute 15.0%
O=C1CCCN1c1cccc(CCO)c1
1-[3-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone
Ausbeute 15.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurification

Vorschrift

The title compound was prepared in 15% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 2-(3-bromophenyl)ethanol and 2-pyrrolidinone. Purification was achieved by flash chromatography on silica gel eluting with ethyl acetate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06