Reaktion #44153

Reaktionsgleichung

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   WaschenThe organic layer was washed with water
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

Vorschrift

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

Quelle