Reaktion #441347

Reaktionsgleichung

3-ethyl-2-(2-methoxyethyl)-4-nitro-pyrazole-5-carboxamide

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product

Ausbeute 79.4%

4-Amino-3-ethyl-2-(2-methoxyethyl)-pyrazole-5-carboxamide

Ausbeute 79.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Einengenconcentrated
3. 3
   SonstigeRecrystallisation from hot ethyl acetate

Vorschrift

10% Palladium on carbon (100 mg) was added to a stirred slurry of 3-ethyl-2-(2-methoxyethyl)-4-nitro-pyrazole-5-carboxamide (5 g, 20.77 mmol) in ethanol (100 mL) and the mixture stirred in a pressure vessel under a hydrogen atmosphere (344.7 kPa (50 psi)) at room temperature for 6 h. The mixture was filtered and concentrated. Recrystallisation from hot ethyl acetate gave the product as white crystals (3.5 g). The mother liquor was concentrated to give a further 1.5 g of product as a grey powder.

Quelle