Reaktion #44099

Reaktionsgleichung

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

hydrochloric acid

→

title compound

Ausbeute 80.0%

2-Methyl-5-(1-piperazinyl)quinoline

Ausbeute 80.0%

Lösungsmittel

2-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthen concentrated
2. 2
   workup.ADDITIONWater (30 vol) was added
3. 3
   Extraktionthe solution was extracted with ethyl acetate (3×20 vol)
4. 4
   Extraktionthen extracted with dichloromethane (5×40 vol)
5. 5
   SonstigeThe combined organic extracts were dried
6. 6
   Sonstigeevaporated

Vorschrift

To a solution of 1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate in 2-propanol (3 vol) was added dropwise hydrochloric acid (37%, 3 vol). The mixture was stirred at 40° C. for 1.5 hours then concentrated. Water (30 vol) was added and the solution was extracted with ethyl acetate (3×20 vol). The aqueous layer was basified with an aqueous sodium carbonate solution then extracted with dichloromethane (5×40 vol). The combined organic extracts were dried and evaporated to give the title compound as an off-white solid (80% th, 2 steps).

Quelle