Reaktion #44097

Reaktionsgleichung

1-[3-(2-hydroxyethyl)phenyl]-2-imidazolidinone

Triethylamine

methanesulfonyl chloride

→

title compound

Ausbeute 90.0%

2-[3-(2-Oxo-1-imidazolidinyl)phenyl]ethyl methanesulfonate

Ausbeute 90.0%

Lösungsmittel

acetonitrile

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe mixture was washed with a saturated solution of ammonium chloride (2×3 vol)
2. 2
   EinengenThe organic phase was concentrated to 5 vol, ethyl acetate (5 vol)
3. 3
   workup.ADDITIONwas added
4. 4
   Sonstigethe solution was evaporated to dryness

Vorschrift

Alternatively, 1-[3-(2-hydroxyethyl)phenyl]-2-imidazolidinone was suspended in acetonitrile (5 vol) at room temperature and under nitrogen. Triethylamine (1 vol) was added dropwise over 15 minutes. The mixture was cooled to 0° C. and methanesulfonyl chloride (0.73 vol) was added over 30 minutes. The reaction mixture was stirred at room temperature for 2 hours, then diluted with ethyl acetate (10 vol). The mixture was washed with a saturated solution of ammonium chloride (2×3 vol), followed by water-brine 1:1 (2×3 vol). The organic phase was concentrated to 5 vol, ethyl acetate (5 vol) was added and the solution was evaporated to dryness, yielding the title compound as a cream-coloured solid (yield: 90% th).

Quelle