Reaktion #44070

ord-372fb67705f345648d2f6bb844c3eb6f

Reaktionsgleichung

Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
CC(C)(C)CC(=O)Cl
3,3-dimethylbutanoyl chloride
→
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)CC(C)(C)C)c4)CC3)cccc2n1
title compound
Ausbeute 62.0%
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)CC(C)(C)C)c4)CC3)cccc2n1
3,3-Dimethyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl) butanamide
Ausbeute 62.0%

Edukte

—
amides
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
CC(C)(C)CC(=O)Cl
3,3-dimethylbutanoyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in 62% yield according to the general procedure for the preparation of the amides (Method B) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 3,3-dimethylbutanoyl chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06