Reaktion #44060

ord-1a371ec5f0954aadba4ca9cc774c215b

Reaktionsgleichung

Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
D5
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
2-Methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
7-chloro-2-methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
7-Chloro-2-methyl-5-(1-piperazinyl)quinoline
O=[N+]([O-])c1ccc(S(=O)(=O)OCCc2cccc([N+](=O)[O-])c2)cc1
2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonate
→
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cc(Cl)cc2n1
title compound
Ausbeute 92.0%
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cc(Cl)cc2n1
7-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline
Ausbeute 92.0%

Edukte

Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
D5
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
2-Methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
7-chloro-2-methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
7-Chloro-2-methyl-5-(1-piperazinyl)quinoline
O=[N+]([O-])c1ccc(S(=O)(=O)OCCc2cccc([N+](=O)[O-])c2)cc1
2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in 92% yield using a similar procedure to description D5 starting from 7-chloro-2-methyl-5-(1-piperazinyl)quinoline (D16) and 2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonate (D15).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06