Reaktion #44059

ord-13294da39753479ab5e595d8d3b068b3

Reaktionsgleichung

Cc1ccc2c(N3CCNCC3)cccc2n1
D3
Cc1ccc2c(N3CCNCC3)cccc2n1
2-Methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(OS(=O)(=O)C(F)(F)F)cccc2n1
D1
Cc1ccc2c(OS(=O)(=O)C(F)(F)F)cccc2n1
2-Methyl-5-quinolinyl trifluoromethanesulfonate
Cc1ccc2c(O)cc(Cl)cc2n1
7-chloro-5-hydroxy-2-methylquinoline
Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1
D2
Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1
1,1-Dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate
→
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
title compound
Cc1ccc2c(N3CCNCC3)cc(Cl)cc2n1
7-Chloro-2-methyl-5-(1-piperazinyl)quinoline

Edukte

Cc1ccc2c(N3CCNCC3)cccc2n1
D3
Cc1ccc2c(N3CCNCC3)cccc2n1
2-Methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(OS(=O)(=O)C(F)(F)F)cccc2n1
D1
Cc1ccc2c(OS(=O)(=O)C(F)(F)F)cccc2n1
2-Methyl-5-quinolinyl trifluoromethanesulfonate
Cc1ccc2c(O)cc(Cl)cc2n1
7-chloro-5-hydroxy-2-methylquinoline
Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1
D2
Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1
1,1-Dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 7-chloro-5-hydroxy-2-methylquinoline (WO/0234754) using similar procedures to descriptions D1, D2 and D3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06