Reaktion #44057

ord-5db34a42240e480c884c3e96136bf5ea

Reaktionsgleichung

Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
D5
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
2-Methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline
Cc1ccc2c(N3CCNCC3)cccc2n1
2-methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(N3CCNCC3)cccc2n1
2-Methyl-5-(1-piperazinyl)quinoline
CS(=O)(=O)OCCc1cccc(Br)c1
2-(3-bromophenyl)ethyl methanesulfonate
→
Cc1ccc2c(N3CCN(CCc4cccc(Br)c4)CC3)cccc2n1
title compound
Ausbeute 56.0%
Cc1ccc2c(N3CCN(CCc4cccc(Br)c4)CC3)cccc2n1
5-{4-[2-(3-Bromophenyl)ethyl]-1-piperazinyl}-2-methylquinoline
Ausbeute 56.0%

Edukte

Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
D5
Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)cccc2n1
2-Methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline
Cc1ccc2c(N3CCNCC3)cccc2n1
2-methyl-5-(1-piperazinyl)quinoline
Cc1ccc2c(N3CCNCC3)cccc2n1
2-Methyl-5-(1-piperazinyl)quinoline
CS(=O)(=O)OCCc1cccc(Br)c1
2-(3-bromophenyl)ethyl methanesulfonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in 56% yield using a similar procedure to description D5 starting from 2-methyl-5-(1-piperazinyl)quinoline (D3) and 2-(3-bromophenyl)ethyl methanesulfonate (D13).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06