Reaktion #440534

Reaktionsgleichung

chlorotrimethysilane

Artemisinin

dextrose

Sodium borohydride

→

beta arteether

Ausbeute 72.8%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was further stirred for 1.5 hours at room temperature
2. 2
   SonstigeAfter usual work up and purification through column chromatography (1:5 ratio)
3. 3
   workup.ADDITIONa mixture of alpha

Vorschrift

Artemisinin (1 g.) and polyhydroxy catalyst, dextrose (4 g.) were stirred in ethanol (15 ml). Sodium borohydride (500 mg.) was added slowly for 10 minutes and the reaction mixture was stirred for 30 minutes at room temperature (20-23° C.). After completion of the reduction step, chlorotrimethysilane (3.5 ml) was added and the reaction mixture was further stirred for 1.5 hours at room temperature. After usual work up and purification through column chromatography (1:5 ratio) a mixture of alpha and beta arteether (0.805 g., 80.5% w/w) were obtained.

Quelle