Reaktion #44047

Reaktionsgleichung

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

1,1-Dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

trifluoroacetic acid

→

title compound

Ausbeute 96.0%

2-Methyl-5-(1-piperazinyl)quinoline

Ausbeute 96.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure

Vorschrift

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).

Quelle