Reaktion #44027
ord-644b876f706048c9b1a88b5f583d5ae9
Reaktionsgleichung
hydrazine hydrate
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate
compound 67
benzyl 2-(4-chlorophenyl)-4-oxopiperidine-1-carboxylate
compound 50
piperidin-4-one
isopropylmagnesium chloride
→
benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate, prepared as described for compound 67 in Example 3 using isopropylmagnesium chloride, was formylated and treated with hydrazine hydrate as described for compound 50 in Example 1 to give benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate. This compound was then deprotected and treated with 4-chlorophenylsulfonyl chloride followed by NaOH as described for compound 52 in Example 1.