Reaktion #439730

ord-c810ab144a56409e95625bf153d14036

Reaktionsgleichung

CC(C)c1cc(Oc2c(Cl)c(F)nc(NCC(=O)O)c2Cl)ccc1O
3,5-dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonyl-methylaminopyridine
CC(C)c1cc(Oc2c(Cl)c(F)nc(NCC(=O)O)c2Cl)ccc1O
3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonylmethylaminopyridine
CC(C)[CH2][Al][CH2]C(C)C
Dibal-H
→
CC(C)c1cc(Oc2c(Cl)c(F)nc(NCCO)c2Cl)ccc1O
3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxyethylamino)pyridine

Edukte

—
methyl ester
CC(C)c1cc(Oc2c(Cl)c(F)nc(NCC(=O)O)c2Cl)ccc1O
3,5-dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonyl-methylaminopyridine
CC(C)c1cc(Oc2c(Cl)c(F)nc(NCC(=O)O)c2Cl)ccc1O
3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonylmethylaminopyridine
CC(C)[CH2][Al][CH2]C(C)C
Dibal-H

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By reduction of the methyl ester of 3,5-dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-hydroxycarbonyl-methylaminopyridine (example 2), with Dibal-H in THF.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06747048B2uspto-grants-2004_06