Reaktion #439626

Reaktionsgleichung

4-hydrox-phenylaniline

2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-ol

triphenylphosphine

diisopropyl azodicarboxylate

→

title compound

Ausbeute 62.0%

{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-phenyl-amine

Ausbeute 62.0%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   Sonstigethe residue purified by chromatography (SiO2, n-hexane/AcOEt 6:1)

Vorschrift

To a solution of 0.50 g 4-hydrox-phenylaniline, 0.83 g of 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-ol and 1.06 g of triphenylphosphine in 20 ml of THF was added at 0° C. a solution of 0.82 g of diisopropyl azodicarboxylate in 10 ml of THF over 30 min and stirring was continued at 22° C. for 5 h. The mixture was evaporated and the residue purified by chromatography (SiO2, n-hexane/AcOEt 6:1) to give 0.62 g of the title compound as a colorless solid. MS: (M+H)+ 371.4.

Quelle